Research Evidence Source : Llinás R, Ribary U. Coherent 40-Hz oscillation characterizes dream state in humans. Proc Natl Acad Sci. USA 1993; 90: 2078-2081. doi:10.1073/pnas.90.5.2078.
Short Research Summary: This study with MEG recording demonstrated that using a frequency sweep of sound-based stimulation “resets” crucial gamma brain activity. SONIK application: Since central pain may result from brain circuit dysregulation, a sound-based vibration “sweep” in the gamma range has the potential to reset this and contribute to pain reduction.

SONIK reduces pain by re-regulating brain circuits
Research Study Abstract:
Magnetic recording from five normal human adults demonstrates large [gamma] coherent magnetic activity in the awake and in rapid-eye-movement (REM) sleep states. It is reduced during delta sleep (deep sleep characterized by delta waves in the electroencephalogram). This magnetic oscillation has been shown to reset by sensory stimuli (sound frequency sweep) in the awake state. Such resetting is not observed during REM or delta sleep. The frequency in REM sleep is characterized in the awake state, by a fronto-occiptal phase shift over the head. This phase shift has a maximum duration of -12-13 msec. Because frequency oscillation is seen in wakefulness and in dreaming, we propose it to be a correlate of cognition, probably resultant from coherent frequency resonance between thalamocortical-specific and nonspecific loops. Moreover, we proposed that the specific loops give the content of cognition, and a nonspecific loop gives the temporal binding required for the unity of cognitive experience.

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